该scroll事件无法取消。但是您可以通过取消这些交互事件来实现：
鼠标 和 触摸滚动以及与滚动相关的按钮。

[工作演示]

// left: 37, up: 38, right: 39, down: 40,
// spacebar: 32, pageup: 33, pagedown: 34, end: 35, home: 36
var keys = {37: 1, 38: 1, 39: 1, 40: 1};

function preventDefault(e) {
  e.preventDefault();
}

function preventDefaultForScrollKeys(e) {
  if (keys[e.keyCode]) {
    preventDefault(e);
    return false;
  }
}

// modern Chrome requires { passive: false } when adding event
var supportsPassive = false;
try {
  window.addEventListener("test", null, Object.defineProperty({}, 'passive', {
    get: function () { supportsPassive = true; } 
  }));
} catch(e) {}

var wheelOpt = supportsPassive ? { passive: false } : false;
var wheelEvent = 'onwheel' in document.createElement('div') ? 'wheel' : 'mousewheel';

// call this to Disable
function disableScroll() {
  window.addEventListener('DOMMouseScroll', preventDefault, false); // older FF
  window.addEventListener(wheelEvent, preventDefault, wheelOpt); // modern desktop
  window.addEventListener('touchmove', preventDefault, wheelOpt); // mobile
  window.addEventListener('keydown', preventDefaultForScrollKeys, false);
}

// call this to Enable
function enableScroll() {
  window.removeEventListener('DOMMouseScroll', preventDefault, false);
  window.removeEventListener(wheelEvent, preventDefault, wheelOpt); 
  window.removeEventListener('touchmove', preventDefault, wheelOpt);
  window.removeEventListener('keydown', preventDefaultForScrollKeys, false);
}

更新：修复了带有被动侦听器的 Chrome 桌面和现代移动浏览器

只需向主体添加一个类即可：

.stop-scrolling {
  height: 100%;
  overflow: hidden;
}

添加该类，然后在您想要重新启用滚动时删除，在 IE、FF、Safari 和 Chrome 中进行了测试。

$('body').addClass('stop-scrolling')

对于移动设备，您需要处理touchmove事件：

$('body').bind('touchmove', function(e){e.preventDefault()})

并取消绑定以重新启用滚动。在 iOS6 和 Android 2.3.3 中测试

$('body').unbind('touchmove')

这是一个非常基本的方法：

window.onscroll = function () { window.scrollTo(0, 0); };

它在 IE6 中有点跳跃。

以下解决方案是基本但纯 JavaScript（无 jQuery）：

function disableScrolling(){
    var x=window.scrollX;
    var y=window.scrollY;
    window.onscroll=function(){window.scrollTo(x, y);};
}

function enableScrolling(){
    window.onscroll=function(){};
}

此解决方案将在禁用滚动时保持当前滚动位置，这与将用户跳回顶部的某些解决方案不同。

它基于galambalazs 的答案，但支持触摸设备，并使用 jquery 插件包装器重构为单个对象。

演示在这里。

在 github 上。

/**
 * $.disablescroll
 * Author: Josh Harrison - aloof.co
 *
 * Disables scroll events from mousewheels, touchmoves and keypresses.
 * Use while jQuery is animating the scroll position for a guaranteed super-smooth ride!
 */

;(function($) {

    "use strict";

    var instance, proto;

    function UserScrollDisabler($container, options) {
        // spacebar: 32, pageup: 33, pagedown: 34, end: 35, home: 36
        // left: 37, up: 38, right: 39, down: 40
        this.opts = $.extend({
            handleKeys : true,
            scrollEventKeys : [32, 33, 34, 35, 36, 37, 38, 39, 40]
        }, options);

        this.$container = $container;
        this.$document = $(document);
        this.lockToScrollPos = [0, 0];

        this.disable();
    }

    proto = UserScrollDisabler.prototype;

    proto.disable = function() {
        var t = this;

        t.lockToScrollPos = [
            t.$container.scrollLeft(),
            t.$container.scrollTop()
        ];

        t.$container.on(
            "mousewheel.disablescroll DOMMouseScroll.disablescroll touchmove.disablescroll",
            t._handleWheel
        );

        t.$container.on("scroll.disablescroll", function() {
            t._handleScrollbar.call(t);
        });

        if(t.opts.handleKeys) {
            t.$document.on("keydown.disablescroll", function(event) {
                t._handleKeydown.call(t, event);
            });
        }
    };

    proto.undo = function() {
        var t = this;
        t.$container.off(".disablescroll");
        if(t.opts.handleKeys) {
            t.$document.off(".disablescroll");
        }
    };

    proto._handleWheel = function(event) {
        event.preventDefault();
    };

    proto._handleScrollbar = function() {
        this.$container.scrollLeft(this.lockToScrollPos[0]);
        this.$container.scrollTop(this.lockToScrollPos[1]);
    };

    proto._handleKeydown = function(event) {
        for (var i = 0; i < this.opts.scrollEventKeys.length; i++) {
            if (event.keyCode === this.opts.scrollEventKeys[i]) {
                event.preventDefault();
                return;
            }
        }
    };


    // Plugin wrapper for object
    $.fn.disablescroll = function(method) {

        // If calling for the first time, instantiate the object and save
        // reference. The plugin can therefore only be instantiated once per
        // page. You can pass options object in through the method parameter.
        if( ! instance && (typeof method === "object" || ! method)) {
            instance = new UserScrollDisabler(this, method);
        }

        // Instance already created, and a method is being explicitly called,
        // e.g. .disablescroll('undo');
        else if(instance && instance[method]) {
            instance[method].call(instance);
        }

    };

    // Global access
    window.UserScrollDisabler = UserScrollDisabler;

})(jQuery);